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Title: Modification of Polycaprolactone Nanofibrous Mat by Laminin Protein and Its Cellular Study
Journal: Journal of Biomaterials and Tissue Engineering
Author: 1. ali sahebalzamani, 2. Esmaeil Biazar
Year: 2014
Address:
Abstract: Nanofibers have improved the performance of biomaterials, and could be considered effective. In this study, Polycaprolactone (PCL) nanofibers were well designed then modified and cross-linked by oxygen plasma and laminin. The samples were evaluated by attenuated total reflectance-fourier transform infrared spectroscopy (ATR-FTIR), scanning electron microscope (SEM), contact angle, Mechanical analyses and finally, cell culture. ATR-FTIR structural analysis showed the presence of functional groups on the nanofibrous surfaces. The SEM images showed the average size of nanofibers to be about 100–300 nm for samples. The 76 difference was obtained in the contact angle analysis, obtained for the laminin–cross-linked nanofibrous mat than the un-modified nanofibrous mat. Cellular investigation showed better adhesion and cell growth and proliferation of laminin crosslinked nanofibrous samples than other samples. The bioavailability of PCL fibers with covalently attached laminin was found to be identical to that of PCL fibers with physically adsorbed laminin, indicating that covalent attachment of protein is a suitable method for enhancing the biocompatibility of tissue engineering scaffolds.
Keywords: CELLULAR INVESTIGATION; LAMININ; NANOFIBROUS PCL; PLASMA TREATMENT; SURFACE MODIFICATION
Application: Tissue Engineering
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URL: http://www.ingentaconnect.com/content/asp/jbte/2014/00000004/00000006/art00001#="http://www.ingentaconnect.com" & "/content/asp/jbte/2014/00000004/00000006/art00001"#