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Title: Scale-up of Electrospinning: Market Overview of Products and Devices for Pharmaceutical and Biomedical Purposes
Journal: Pharmaceutics
Author: 1. Safaa Omer, Romána Zelkó, István Sebe, 2. László Forgách
Year: 2021
Address: 1. University Pharmacy Department of Pharmacy Administration, Semmelweis University, H˝ogyes Endre Street 7-9, 1092 Budapest, Hungary 2. Department of Biophysics and Radiation Biology, Semmelweis University, T˝uzoltó Street 37-47, 1094 Budapest, Hungary
Abstract: Recently, the electrospinning (ES) process has been extensively studied due to its potential applications in various fields, particularly pharmaceutical and biomedical purposes. The production rate using typical ES technology is usually around 0.01–1 g/h, which is lower than pharmaceutical industry production requirements. Therefore, different companies have worked to develop electrospinning equipment, technological solutions, and electrospun materials into large-scale production. Different approaches have been explored to scale-up the production mainly by increasing the nanofiber jet through multiple needles, free-surface technologies, and hybrid methods that use an additional energy source. Among them, needleless and centrifugal methods have gained the most attention and applications. Besides, the production rate reached (450 g/h in some cases) makes these methods feasible in the pharmaceutical industry. The present study overviews and compares the most recent ES approaches successfully developed for nanofibers’ large-scale production and accompanying challenges with some examples of applied approaches in drug delivery systems. Besides, various types of commercial products and devices released to the markets have been mentioned.
Keywords: electrospinning (ES), nanofibers (NFs), scale-up, pharmaceutical industry
Application: Electrospinning Market in Pharmaceutics
Product Model 1: An overview on all elevtrospinning machines (Industrial, Pilot and Lab-scale)
Product Model 2:
URL: #https://www.mdpi.com/1999-4923/13/2/286#