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Title: Tissue‐engineered nerve graft using silk‐fibroin/polycaprolactone fibrous mats decorated with bioactive cerium oxide nanoparticles
Journal: Journal of Biomedical Materials Research Part A
Author: 1. Mahmoud Azami, Jafar Ai, Somayeh Ebrahimi-Barough, 1,2. Jamileh Saremi, 3. Mehdi Khanmohammadi, 4. Aliakbar Yousefi-Ahmadipour
Year: 2021
Address: 1. Department of Tissue Engineering and Applied Cell Sciences, School of Advanced Technologies in Medicine, Tehran University of Medical Sciences, Tehran, Iran 2. Research Center for Noncommunicable Diseases, Jahrom University of Medical Sciences, Jahrom, Iran 3. Skull Base Research Center, The Five Senses Institute, Hazrat Rasoul Akram Hospital, Iran University of Medical Sciences (IUMS), Tehran, Iran 4. Immunology of Infectious Diseases Research Center, Research Institute of Basic Medical Sciences, Rafsanjan University of Medical Sciences, Rafsanjan, Iran
Abstract: The main aim of this study was to evaluate the efficacy of cerium oxide nanoparticles (CNPs) encapsulated in fabricated hybrid silk-fibroin (SF)/polycaprolactone (PCL) nanofibers as an artificial neural guidance conduit (NGC) applicable for peripheral nerve regeneration. The NGC was prepared by PCL and SF filled with CNPs. The mechanical properties, contact angle, and cell biocompatibility experiments showed that the optimized concentration of CNPs inside SF and SF/PCL wall of conduits was 1% (wt/wt). The SEM image analysis showed the nanoscale texture of the scaffold in different topologies depend on composition with fiber diameters at about 351 ± 54 nm and 420 ± 73 nm respectively for CNPs + SF and CNPs + SF/PCL fibrous mats. Furthermore, contact angle measurement confirmed the hydrophilic behavior of the membranes, ascribable to the SF content and surface modification through modified methanol treatment. The balance of morphological and biochemical properties of hybrid CNPs 1% (wt/wt) + SF/PCL construct improves cell adhesion and proliferation in comparison with lower concentrations of CNPs in nanofibrous scaffolds. The release of CNPs 1% (wt/wt) from both CNPs + SF and CNPs+ SF/PCL fibrous mats was highly controlled and very slow during the extended time of incubation until 60 days. Fabricated double-layered NGC using CNPs + SF and CNPs + SF/ PCL fibers was consistent for application in nervous tissue engineering and regenerative medicine from a structural and biocompatible perspective.
Keywords: artificial neuron conduit, cerium oxide nanoparticles, controlled release, fibrous silk-fibroin (SF)/PCL fiber mats, nerve tissue regeneration
Application: Tissue Engineering
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URL: #https://onlinelibrary.wiley.com/doi/abs/10.1002/jbm.a.37153#